Phytonanoparticles and COVID-19

Abstract

The novel coronavirus disease (COVID-19) pandemic has grasped the entire world due to its high rate of spread with serious public health concern. The scientific community has applied all possible therapeutic strategies to defeat the virus, still the situation is not in control. So, as a fresh approach, the phytonanoparticles can be used as a powerful gadget against COVID-19 because it can be formulated to perform directly concerning the infection, enhancing drug delivery system or by the way of stimulating the immunity of the patient. The plant extract bioactive can offer its antioxidant, anti-inflammatory, immunomodulatory effect for prophylaxis and treatment of SARS-CoV-2. Selective drug targeting of these plant compounds is needed for augmenting drug stability, solubility, increasing drug half-lives in the blood and reducing adverse effects in non-target organs. Green nano-based drugs use plant extract as a bioreduction and capping agent at room temperature. The green nanoparticles can be aimed to decrease the oxidative stress and systemic inflammation of COVID-19 with increased activity and lesser toxicity to normal cells. This review work summarises the antiviral, immunomodulatory, antiinflammatory potential of green nanoparticles biosynthesised with plant derived molecules with advanced delivery systems which has a possibility to act as efficient potential remedy against coronavirus. This review discusses the scientific explorations of phytonanoparticles which can protect human lives from the devastation of SARS-CoV-2 because of its enhanced anticoronavirus biological activity.