Role of Anticholinergic, Uroselective α 1D/1A Blocker, Combination of Two Drugs and Placebo in Treatment of Ureteral Stent Related Discomfort and Urinary Symptoms

Abstract

Introduction: The ureteral stent placement has become a part of urological clinical practice to relieve ureteral obstruction caused by variety of urological condition since 1967. Study aimed to access the role of anticholinergic (Tolterodine), uroselective α 1D/1A blocker (Naftopidil) alone and in combination to evaluate DJ stent related discomfort or pain, lower urinary tract symptoms and impact on quality of life. Materials and methods: This was a randomized double blind placebo controlled comparative prospective clinical study conducted between May 2013 to February 2015 to access the role of anticholinergic (Tolterodine), uroselective α 1D/1A blocker (Naftopidil) alone and in combination to evaluate DJ stent related discomfort or pain, lower urinary tract symptoms and impact on quality of life. Result: Total of 280 patients were enrolled for the study. 33 patients were excluded. We found Naftopidil and combination to be significanty better for pain score, combination being more effective for storage symptoms, voiding symptoms and quality of life scores. Conclusion: Combination of Tolterodine and Naftopidil can be recommended for relief of stent related discomfort and urinary symptoms.