Archive | 2019
A Comparative Study and Correlation of Role of Sonological Features and Endocrinological Markers in Establishing Diagnosis In Clinically Suspected Cases of Polycystic Ovarian Disease
Abstract
Introduction: Polycystic ovarian syndrome (PCOS) is a common endocrine disorder of women. The cardinal features are hyperandrogenism and oligo-anovulation. A nearly universal finding is an increased Gonadotropin releasing hormone pulse frequency which favors luteinizing hormone production over follicle stimulating hormone. Increased LH subsequently promotes theca cell production of androgens, while relative FSH deficiency reduces the ability of granulose cells to convert androgen into estrogen and impairs follicle maturation and ovulation. Ultrasonography is usually performed as a first step in the in clinically suspected cases of PCOD. Using hyperandrogenism to establish diagnosis of PCOD in suspected cases and then comparing them. Hence, the aim of the present study was to assess the role of sonographic features and hyperandrogenism in establishing diagnosis in PCOD patients. Material and Methods: Total Fifty two (52) patients with suspected PCOD were evaluated using ultrasonological and clinical/biochemical signs of hyperandrogenism. Data regarding hyperandrogenism (clinically hirsutism and serum TT) and ultrasonography changes in ovaries were collected. Relevant clinical assessment included assessment of hirsutism if present as per modified Ferriman Gallwey score system. Results: It was found that sonological changes were present in significant number of PCOD patients 77% with p value 0.0006, similarly clinical or hormonal hyperandrogenism were also present in significant number of patients 35% with p value 0.003.In only 6 patients both sonological and the hyperandrogenism were observed. Conclusion: Ultrasonographic features of ovarian morphology have substantial diagnostic potential to distinguish between women with PCOS and healthy women