Plasma PARK7 and NDKA in acute stroke: methodological issues regarding diagnostic value

Abstract

I read a recently published article by Tulantched et al. in Future Science OA. The purpose of this study was to compare the diagnostic value of plasma PARK7 and NDKA in early diagnosis of acute stroke and evaluate the validated diagnostic values of PARK7 and NDKA in an independent patient cohort. The authors state that the expression of PARK7 (area under the curve = 0.89) in acute stroke patients was more significant than in controls, relative to the NDKA expression (area under the curve = 0.462); p < 0.05. Finally, they concluded that even though both markers cannot differentiate stroke etiologies (ischemic or hemorrhagic), plasma PARK7 has better diagnostic value than NDKA for early diagnosis of stroke [1]. The authors conclusions and comments are further summarized briefly in the highlighted sentences here: