Letter to the Editor Regarding the Article, “Lithium in Late-Life Mania: A Systematic Review” [Letter]

Abstract

*These authors contributed equally to this work Dear editor We read the article “Lithium in late-life mania: a systematic review” by Fazio et al with great interest. The authors conducted this systematic review to evaluate lithium’s role in treating mania in late-life onset bipolar disorder (BD). The study assessed the efficacy and tolerability of lithium for treating late-life onset BD based on the published literature utilizing Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines. However, we humbly like to bring the reader’s attention to the study’s methodology section that can influence the study results. We have mentioned these concerns below in the order of their appearance in the article: