Vector Analysis Reveals That Topography-Guided LASIK Targeting the Manifest Refraction (MR) is Superior to Topography-Modified Refraction (TMR) and Layer Yolked Reduction of Astigmatism (LYRA) [Letter]

Abstract

*These authors contributed equally to this work Dear editor We read with interest “Primary Topography-Guided LASIK: A Comparative Study Comparing Treating the Manifest versus the Topographic Astigmatism”. We commend the authors for performing vector analysis of surgical astigmatic changes using the standardized Alpins Method for their outcomes analysis paper. However, the papers’ conclusion is not supported by the vector analysis findings. Astigmatism vector analysis answers the following clinical questions: 1 – Was the attempted astigmatic treatment undercorrected or overcorrected? 2 – Was the under/overcorrection due to the magnitude or axis of treatment? 3 – Was there a consistent axis error? Vector analysis is therefore essential for a complete evaluation of excimer surgical outcomes and for determining optimal nomogram adjustments to improve future outcomes. Refractive surgery journals have made this type of analysis the standard for reporting. The Alpins difference vector (DV) represents the vectorial difference, in diopters (D), between the desired target surgical treatment of astigmatism (TIA) and the achieved treatment that was induced (SIA). DV is small when the treatment is accurate and large when the treatment is inaccurate. The DV provides the most valuable statistical basis for comparing multiple surgical treatment options. Aboalazayem et al compared treating the manifest refractive astigmatism (Manifest group), vs the anterior corneal astigmatism with spherical adjustment (Full TMR group), vs the anterior corneal astigmatism without spherical adjustment (Partial TMR group). They concluded that treating the anterior corneal astigmatism is best. Yet their data shows superior vector analysis outcomes in the Manifest group, where the difference vector (DV) was as low as 0.20 D, compared to 0.90 D in the Full TMR group, or 0.50 D in the Partial TMR group. These results indicate that eyes in the TMR group and Partial TMR group had by far the greatest astigmatism treatment errors postoperatively in this comparative study. It is hard to reconcile how these groups are presented as having better vision. In addition, the coefficient of determination (R) between the TIA and SIA was 0.82 in the Manifest Correspondence: Avi Wallerstein 1250 Rene-Levesque Blvd W, MD Level, Montreal, QC, H3B 4W8 Tel +1 514-908-9888 Ext 2273 Email [email protected]