The Egyptian Journal of Chemistry | 2021
Aescin Ameliorates Acute Kidney Injury Induced by Potassium Dichromate In Rat: Involvement of TLR 4/ TNF-α Pathway
Abstract
Acute kidney injury (AKI) exhibited more than 1 million deaths every year worldwide; inflammation has a vital role in AKI development and considered as a risk factor in its progression. Aescin is a natural compound with anti-inflammatory vasoconstrictor and vasoprotective effects. The current study aimed to assess Aescin’s possible renal protective and therapeutic effect on potassium dichromate (PD)-induced AKI in rats. Single injection of PD was causing AKI (15 mg/kg; s.c). Rats were divided randomly into four groups. Group I: Normal control. Group II: Rats injected with PD and served as AKI group. Group III: Rats received a daily injection of Aescin for 2 weeks (3.6 mg/Kg; orally), prior PD injection and group IV after PD injection. Kidney functions, kidney contents of inflammatory and proliferative markers as toll-like receptor4 (TLR4), tumour necrosis factor-alpha (TNF-α), heat shock protein-70 (HSP-70) and insulin growth factor-1 (IGF-1) were estimated. In addition, histopathological examination was performed. Aescin improves kidney functions, alleviated inflammatory and proliferative markers and ameliorated hyaline materials in the Bowman s space and necrosis of proximal convoluted tubules that induced by PD. The present study confirmed the effectiveness of use of Aescin in AKI protection or treatment.