Safety and Efficacy of Auto-lipofilling in Facial Rejuvenation: a meta-analysis study

Abstract

Abstract Background: Autologous fat transfer has been practiced and described as a promising method in facial rejuvenation. Many randomized and observational studies have been published with scanty of evidence came from review and meta-analysis. This study aims to evaluate the evidence-based practice regarding the efficacy and safety of autologous fat transfer in an updated meta-analysis study. Method: Systemic review and meta-analysis using (PRI SMA) statement was achieved. Literature search was performed in PubMed, PLOS and Cochrane library. Many of the search engines have been used including EKB platform to download the articles from SCOPUS and Clarivate databases, starting from 2017 to 2021. Results: Out of 132 articles only 6 articles were included in this study. Study included 255patients in total with an average follow-up only for 12 months. Total sessions for all patients in all studies were once for every patient. Analysis showed an overall longevity 68 %, and one study reported complication rate about 5 %. Three studies reported overall surgeon satisfaction and patient satisfaction were 89%, 81% respectively. Conclusion: Although this updated meta-analysis in the period from 2017 to 2021but still the evidence of autologous fat transfer efficacy regards longevity more than one year is still limited to have an evidence-based practice. Well-designed multicentric randomized clinical trials and big series cohort studies are strongly recommended to properly conclude about the efficacy, longevity, and satisfaction.