Amelorative effects of anethum graveolens (Dill) against lornoxicam toxicity in rats

Abstract

Lornoxicam (LOR) is a non-steroidal anti-inflammatory drug known to induce hepato-renal toxicity. The following study aimed to investigate the adverse effect of LOR in oxidative status beside biochemical and histological examination of Liver and kidney tissue as well as the protective effect ofDill. Thirty six male Wister albino rats were randomly divided into main four groups of nine rats each were used; G(1)Control group and they were administered 0.5ml of saline orally for 21 consecutive days, G (2):they were administered 2g/kg dill orally for 21consecutive days, G (3): they were administered 1.3 mg/kg body weight/day of LORintraperitonially for 21 consecutive days, G (4): they were administered 2g/kg dill orally concurrently with 1.3 mg/kg body weight/day of LOR. The results revealed that LOR induced significant increases in liver and kidney function parameters including AST, ALT, creatinine, and urea. Disrupted lipid metabolism also was observed in LOR-treated animals. Moreover, marked an increase in malondialdehyde (MDA) and decreases in glutathione (GSH) and catalase (CAT) following LOR-insult suggested a possible involvement of lipid peroxidation in LOR-induced hepatorenal toxicity.Oral administration of dill at the dose 2g/kg for 21 days was significantly mitigating these toxic effects.So it is concluded that dill has great hepatorenal, antioxidant and antiopoptotic effect.