Clinical Usefulness of N-terminal Prohormone of Brain Natriuretic Peptide and High Sensitivity Troponin T in Patients with Heart Failure Undergoing Cardiac Resynchronisation Therapy.

Abstract

BACKGROUND\nCardiac resynchronisation therapy (CRT) has a well-established position of treatment of selected groups of patients with heart failure (HF). Unfortunately, the percentage of CRT non responders is estimated at around 20% to nearly 50%.\n\n\nOBJECTIVES\nThe aim of our work is to assess the usefulness of N terminal Prohormone of Brain Natriuretic Peptide (NT proBNP) and High Sensitivity Troponin T (cTnThs) in evaluating the response to CRT in a 12month observation.\n\n\nMATERIALS AND METHODS\nThe study included 46 patients with HF and implanted CRT D. We estimated NT proBNP and cTnThs concentrations in 12 months follow up.\n\n\nRESULTS\nWe studied 46 patients (76% men) mean age of 64±8. The criteria for response to CRT were met by 26 patients (56,5%). We documented a significant decline in the NT proBNP concentrations in responders (p=0,001); ΔNT proBNP by at least 579 pg/ml with good sensitivity and specificity identified the responders to CRT. There were no statistically significant differences in the results of cTnThs in both study groups.\n\n\nCONCLUSION\nThe relative change in the concentration of NT proBNP by at least 43,5% permits to identify the responders to CRT during the 12 months follow up. Serial measurements of NT proBNP can provide a valuable tool for monitoring the effectiveness of CRT.