Medicinal chemistry (Shariqah (United Arab Emirates)) | 2021
Anti-infective Potential of Manzamine Alkaloids - A Review.
Abstract
BACKGROUND\nFrom time immemorial, natural products have been used for the treatment of various diseases. Various natural products, their semisynthetic derivatives, and synthetic analogs have been explored for their anti-infective properties. One such group of natural compounds that have been widely explored is manzamine alkaloids. Manzamine alkaloids are complex natural compounds consisting of a β-carboline nucleus attached to a pentacyclic ring system that was first isolated from a marine sponge during the 1980s.\n\n\nOBJECTIVE\nThe review aims to provide a critical overview of the anti-infective potential of manzamine alkaloids.\n\n\nMETHOD\nA comprehensive and exhaustive review of the literature on manzamine alkaloids consisting of their isolation, anti-infective properties, and mechanism of action is presented.\n\n\nRESULTS\nVarious manzamine alkaloids have been isolated and found to exhibit potent anti-infective activities like antibacterial, antimalarial, antiviral, antifungal, antileishmanial, among others. These manzamine alkaloids exhibit their anti-infective activity by inhibiting targets like GSK-3β and MtSK.\n\n\nCONCLUSION\nThis present review with structure-activity relationship study of manzamine alkaloids for their anti-infective activity will be useful for further development of semisynthetic manzamine analogs as potent anti-infective agents with better therapeutic potential and reduced toxicity.