Evaluation of Different Sedatives for Colonoscopy.

Abstract

BACKGROUND & AIMS\nSedation and analgesia are important elements of endoscopic examinations, to sedate patients and help the patients and the endoscopists to feel comfortable. Different sedatives are used; these should be administered with caution, and patients should be continuously monitored during the procedure. The aim of the work was to evaluate and compare different sedative drugs used during colonoscopy.\n\n\nMETHODS\nThe study was carried out on 150 patients who were referred for colonoscopy; they were divided into two groups based on the pre-endoscopic sedation given for them: propofol fentanyl or propofol ketamine. Detailed histories, thorough physical examinations, routine laboratory investigations, were performed for all patients, along with monitoring of their vital signs and oxygen saturation levels (before, during and after colonoscopy), to assess safety, efficacy, recovery times, complications of the sedative drugs and the comfort of the patients and endoscopists.\n\n\nRESULTS\nThere was no statistically significant difference between the two groups in terms of age, sex and body mass indexes (BMI). With respect to their MAPs and heart rates, there was more hemodynamic stability in the propofol ketamine group, and both groups were efficacious, although the propofol fentanyl group had shorter recovery times than the propofol ketamine group (3±1.7 minutes and 4±2.8 minutes, respectively). However, nausea, vomiting and hypoxia were common in the propofol fentanyl group, while hallucinations were common in the propofol ketamine group.\n\n\nCONCLUSION\nSedation with propofol ketamine during colonoscopy was found to be safe and efficacious and to achieve hemodynamic stability with fewer complications than propofol fentanyl.