Magic Shotgun Nature with Scattergun Approach of Curcumin Repurposing in Obsessive-Compulsive disorder: A Novel Metaphysician of Drug Discovery.

Abstract

BACKGROUND\nObsessive-compulsive disorder (OCD) is an intricate, debilitating neuropsychiatric disorder. Exclusively Selective serotonin reuptake inhibitors (SSRIs) are effective agents use for the treatment of OCD. However, SSRIs (Selective serotonin reuptake inhibitors) are not a magic pill-they do not respond adequately to everybody. In this consideration, a single drug target (magic bullet) is only a slightly superior option for all patients with a lot of pathognomic signs.\n\n\nOBJECTIVE\nThe principal aim of the current study was to check the potential contribution of repurposing of magic shotgun nature of curcumin (rhizomes of Curcuma longa) with scattergun approach-proceeding a pioneer fine-tune for obsessive-compulsive disorder.\n\n\nMETHOD\nSwiss albino mice (male 20 to 25 gram) were grouped into different groups (n = 6) used for MBB (marble-burying behaviour) and MA (motor activity) test as a model for evaluation of anti-compulsive activity (Anti-OCD). Ethanolic extract of Curcuma longa (EECL-10, 15, 25, 40 mg/kg), or SSRI (fluoxetine 5,10, 15 mg/kg) followed by pre-treated with either sub-effective dose of fluoxetine, or neurotoxin p-chlorophenyl alanine and specific 5-HT receptors agonists/ antagonist, intraperitoneally.\n\n\nRESULTS\nEECL (40 mg/kg) significantly attenuated the MBB. Although, during treatments, none of the above had any critical impact on MA. p < 0.05 was considered significant in every case.\n\n\nCONCLUSION\nMultiple drug-target interactions with multifarious biogenic receptors supervene unexpected side effects followed by the repurposing of wanted effects (scattergun effect) evoked by curcumin treatment. Ultimately, the study gives the anti-compulsive activity of EECL (curcumin), which was revealed to be mediated through neuromodulation with 5-HT receptors.