Endocrine, metabolic & immune disorders drug targets | 2019

Probiotics Efficacy on Oxidative Stress Values in Inflammatory Bowel Disease: A Randomized Double-Blinded Placebo-Controlled Pilot Study.

 
 
 
 
 
 
 
 
 

Abstract


BACKGROUND\nInflammatory bowel diseases (IBD), which include Crohn s disease (CD) and ulcerative colitis (UC), are described as a chronic inflammation of the small intestine and colon, caused by a dysregulated immune response to host intestinal microbiota in genetically susceptible subjects.\n\n\nOBJECTIVE\nThe aim of this study was to compare probiotic therapy versus placebo in Oxidative Stress Values and clinical features in patients affected by IBD.\n\n\nMETHOD\nForty (40) patients previously diagnosed for IBD were recruited and randomized to receive probiotics (test group, n=20) or placebo (control group, n=20) administered for 90 days. Subjects in both the groups were assessed for overall oxidant ability (d-ROMs test) and for the antioxidant response (BAP test): data were reported at baseline, after 1 and 3 months. Additional data from anamnesis and haematological investigation were also reported during the study.\n\n\nRESULTS\nd-ROM assay clearly showed that the values observed in the test group were significantly improved, leading to oxidative stress values which are not pathological. The test group showed increasing BAP values, thus confirming the overall improvements of patients health following administration of probiotics.\n\n\nCONCLUSION\nOral administration of the specific probiotics demonstrated its efficacy and safety on patients affected by IBD.

Volume 19 3
Pages \n 373-381\n
DOI 10.2174/1871530319666181221150352
Language English
Journal Endocrine, metabolic & immune disorders drug targets

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