Current aging science | 2021
Type 2 Diabetes Mellitus Related to Decreased Peripheral and Respiratory Muscle Strength in sarcopenic Thai Elderly.
Abstract
BACKGROUND\nAge is related to a decline in muscle mass and physical function in respiratory and peripheral muscle strength, leading to mobility and mortality. In addition, older people have suffered from one or multiple chronic conditions, particularly type 2 diabetes mellitus (type 2DM). However, few studies have reported the relationship between sarcopenic elderly and respiratory and peripheral muscle strengths in type 2DM.\n\n\nOBJECTIVE\nTo explore the prevalence of sarcopenia in type 2DM elderly people among community dwelling patients and the relationships with peripheral and respiratory muscle loss in sarcopenic type 2DM older patients.\n\n\nMETHODS\nA total of 330 older individuals were recruited from community-dwelling centers. Respiratory muscle and quadriceps muscle were assessed. According to the defined criteria for sarcopenia (defined by Asian Working Group for Sarcopenia), muscle mass, gait speed (six-meter walk test) and handgrip strength were examined.\n\n\nRESULTS\nOf 330 older people, 82 volunteers had a history of type 2DM. Participants with type 2DM had a risk for sarcopenia (odds ratio= 2.324, 95% CI=1.251-4.317). The prevalence of sarcopenia was 25.61% among older participants with type 2DM. In addition, decreased respiratory muscle strength and quadriceps muscle strength was observed in type 2DM with sarcopenia compared to type 2DM with non-sarcopenia. These relationships also remained after controlling for age and sex.\n\n\nCONCLUSION\nsarcopenia in type 2DM leads to a decrease in respiratory muscle and peripheral muscle strength.