In Vivo Study of New Oral Docetaxel -Loaded Nanomicelles

Abstract

Poor solubility, low bio-stability, and the high toxicity of docetaxel medicine result in limited consumption, common side effects, and low efficacy. The current commercial form of the product, Taxotere®, with intravenous administration caused hypersensitivity due to hemolysis by separating hemoglobin and red blood cells. In addition, the patient suffers from a severe treatment regime through prolonging medicine injection. The most important advantages of medicine in cancer treatment are to consider patients comfort, and acceptance during treatment, as well as to choose the most effective medicine to achieve the highest improvement in cancer cells. Following our previous study, in this study stabilized docetaxel loaded nanomicelles were used for the treatment of mice with C26 colon carcinoma. The synthesized nanomicelles have satisfying results on animal trials and adequate characters such as an oral form of medicine, particle size of less than 15 nm, proper PDI, sufficient zeta potential for physical stability and maintaining particle size, non-toxicity of career, and high efficacy than the commercial product Taxotere®. In addition, lower side effects of synthesized oral form medicine on the treatment of C26 colon carcinoma can be named as the other advantage of this study.