Anaplastic Wilms’ Tumor Mimicking a Rhabdoid Tumor: A Diagnostic Challenge:

Abstract

Rhabdoid tumor of the kidney (RTK) mimics other renal tumors \nhistologically, but a rhabdoid tumor mimicking an anaplastic Wilms’ \ntumor has been rarely reported. Wilms’ tumor classically comprises \nthree histological components, including a blastema, epithel \nium, and stroma. The degree of maturation of these components makes the \nhistological appearance of this tumor unique. Anaplasia is defined by \nthe presence of extreme nuclear and mitotic atypia. Most of these \nlesions can be differentiated on the basis of light microscopic \nhistological investigations. Herein we report a case of pediatric \nanaplastic Wilms’ tumor that was difficult to differentiate from a mesenchymal lesion histologically. \nThe application of immunohistochemistry and extensive sampling of the lesion was critical for accurate diagnosis. \nKeywords: \nWilm’s Tumor; Child; Rhabdoid Tumor.