Carbapenems in clinical practice

Abstract

Increasing frequency of infections caused by multi-drug resistant organisms is currently observed in the adult and pediatric population. It is the clinician’s responsibility to use wide-spectrum antibiotics when appropriate, where such a potent treatment is required. Carbapenems are the most efficient beta-lactams, especially against Gram-negative bacilli, and the most preserved from resistance so far. This review summarizes microbiological, pharmacokinetic and pharmacodynamic characteristics of currently available carbapenems. Their clinical use in different pediatric settings is then discussed, based on published evidence. Among available carbapenems, meropenem has superior pharmacokinetic and pharmacodynamic properties, higher tolerance and easier use in the pediatric population.