The state of some cytokines in measles in children

Abstract

According to the Public Health Center of Ukraine, from the beginning of the year (from December 28, 2018, to June 27, 2019), 55,300 people had measles, including 25,987 adults and 29,313 children, and 18 persons died from complications of measles. During the outbreak since summer 2017, more than 110 thousand people were ill with measles, 39 of whom died. Symptomatic and supportive treatment of measles is required. The purpose of the research is to reveal the peculiarities of cytokine status in children with measles and to make the correction with a combined homoeopathic drug Influcid. Materials and methods. Surveillance was carried out for 97 children aged from 3 weeks to 18 years who suffered from measles and underwent inpatient treatment. In children with measles at the onset of the disease and in the dynamics, changes of the cytokine profile were marked. They manifested themselves in an imbalance of proinflammatory and anti-inflammatory cytokines that indicated antiviral defense tension in measles. Treatment of patients was carried out according to local protocols. Children of the study group (n = 45) received Influcid from the first day of inpatient treatment in addition to standard therapy. As a result of the drug use, there was a reduction in the duration of fever by 2.8 days and catarrhal syndrome — by 5.4 days, as well as the normalization of cytokine status.