The efficacy and safety of lenvatinib in the treatment of solid tumors: an up-to-date meta-analysis.

Abstract

Aim: We performed an updated meta-analysis to evaluate the efficacy and safety of lenvatinib in cancer patients. Materials & methods: Databases were searched to identify relevant trials. Data were extracted to evaluate overall survival, progression-free survival, overall response rate and grade ≥3 adverse events. Results: The pooled analysis demonstrated that lenvatinib significantly improved progression-free survival (hazard ratio: 0.43;\xa095% CI: 0.23-0.80; p = 0.008), overall survival\xa0(hazard ratio: 0.85;\xa095% CI: 0.75-0.97; p = 0.013) and overall response rate (relative risk: 6.89;\xa095% CI: 2.22-21.36; p = 0.001) compared with control therapy. However, the use of lenvatinib can increase the risk of severe infection. Conclusion: Lenvatinib-containing regimens are associated with better progression-free survival, overall survival and overall response rate, but can induce severe infection.