Patient-centered outcomes in non-small-cell lung cancer: a real-world perspective.

Abstract

Aims: To assess non-small-cell lung cancer (NSCLC) patient-centered outcomes in the real world. Methods: This is a prospective study of NSCLC patients treated at a private cancer care institution in Brazil between 2014 and 2019. Results: The report comprises 337 patients. Advanced stage was associated with higher symptom burden -\xa0fatigue (p\xa0=\xa00.03), pain (p\xa0<\xa00.001) and arm pain (p\xa0=\xa00.022) - and worse global, social and physical functioning (all p\xa0<\xa00.001). In the first 2\xa0years, most factors evolved to either improvement or stability: cough (p\xa0=\xa00.02), pain (p\xa0=\xa00.002), global functioning (p\xa0<\xa00.001) and emotional functioning (p\xa0<\xa00.001). Staging (p\xa0<\xa00.001), fatigue (p\xa0=\xa00.001)\xa0and gender (p\xa0=\xa00.004) were independently associated with overall survival. Conclusions: Our results demonstrate the feasibility of conducting real-world prospective analysis of patient-centered outcomes.