Pragmatic patient engagement in designing pragmatic oncology clinical trials.

Abstract

Oncology trials are the cornerstone of effective and safe therapeutic discoveries. However, there is increasing demand for pragmatism and patient engagement in the design, implementation\xa0and dissemination of oncology trials. Many researchers are uncertain about making trials more practical and even less knowledgeable about how to meaningfully engage patients without compromising scientific rigor to meet regulatory requirements. The present work provides practical guidance for addressing both pragmaticism and meaningful patient engagement. Applying evidence-based approaches like PRECIS-2-tool and the\xa010-Step Engagement Framework offer\xa0practical guidance to make future trials in oncology truly pragmatic and patient-centered. Consequently, such\xa0patient-centered trials have improved participation, faster\xa0recruitment and greater\xa0retention, and uptake of innovative technologies in\xa0community-based care.