Archive | 2021
Lung Volume Determination by Dual-source Computed Tomography in Infants with Pulmonary Artery Sling
Abstract
Background: Pulmonary artery sling (PAS) is associated with tracheal\nstenosis and left pulmonary artery (LPA) dysplasia in infants, which may\ncause pulmonary dysplasia and lung volume variations. We aimed to assess\nthese altered lung volumes in patients with PAS using dual-source\ncomputed tomography (DSCT). Methods: We retrospectively enrolled\npatients with surgically confirmed PAS and compared them with matched\nnormal controls. All participants underwent DSCT examination. We\nmeasured and compared the diameters of the trachea, main bronchus and\nmain pulmonary artery (MPA) and its branches and both lung volumes on\naxial and reconstructed computed tomography images. Results: There were\nno statistical differences in the diameters of MPA or right pulmonary\nartery between patients and controls. The diameters of the stenosed\ntrachea , left and right main bronchi and LPA were smaller in the PAS\ngroup than in the control group (p < 0.001) , and significant\ndifferences were evident in the left lung volume (p < 0.001),\nright lung volume (p = 0.008) and the right-to-left lung volume ratio (p\n= 0.004) between the two groups. Pearson’s correlation and linear\nregression analyses between the diameters of the trachea and MPA, total\nlung volume, ipsilateral bronchial and pulmonary artery branches and\nipsilateral lung volume ranged from 0.71 to 0.87 (p < 0.001)\nand 0.57 to 0.77 (p < 0.05) for the control and PAS groups,\nrespectively. Conclusions: Lung development is disordered in patients\nwith PAS, which causes not only tracheal stenosis and LPA dysplasia but\nalso dysplasia of both lungs.