Dynamic thiol/disulphide balance in patients undergoing hypotensive anesthesia in elective septoplasties

Abstract

Objective: We aimed to investigate the effects of hypotensive anesthesia\non oxidative stress with serum thiol/disulfide balance in patients\nundergoing elective septoplasty procedures under general anesthesia.\nMethods: Seventy-two patients between the ages of 18-60, with a physical\ncondition I –II, according to the American Society of\nAnesthesiologists, were included in this prospective observational\nstudy. Septoplasty was chosen for standard surgical stress. According to\nthe maintenance of anesthesia, patients were divided into the groups as\nHypotensive Anesthesia (n = 40) and Normotensive Anesthesia (n = 32).\nSerum thiol/disulfide levels were measured by the method developed by\nErel & Neşelioğlu. Results: The native thiol and total thiol values of\nboth groups measured at the 60th minute intraoperatively were\nsignificantly lower than the preoperative values (both p <\n0.01). Intraoperatively, at the 60th minute, there was no significant\ndifference in terms of post-native thiol and post-total thiol levels\nbetween hypotensive and normotensive anesthesia groups (p = 0.68, and p\n= 0.81, respectively). Age > 40 years and female gender\nwere found to have a significant effect on dynamic oxidative stress (p =\n0.002, and p = 0.001, respectively). Conclusion: This pilot study has\nfound that hypotensive anesthesia had no adverse effect on dynamic\nthiol/disulfide balance in elective surgeries.