Assessment of gentamicin effect on oxidoreductive balance and microstructure of trunk kidney in Prussian carp (Carassius gibelio)

Abstract

Assessment of gentamicin effect on oxidoreductive balance and microstructure of trunk kidney in Prussian carp (Carassius gibelio). The aim of this study was to investigate the potential toxic effects of gentamicin on the Prussian carp (Carrasius gibelio) by determining its effect on oxidant-antioxidant balance and by histological image analysis of trunk kidney. The fi shes were injected with single standard therapeutic dose of gentamicin of 5 mg·kg–1. The samples of trunk kidney were collected in 3 days post antibiotic administration. Concentration of reduced glutathione (GSH) and activity of enzymes: superoxide dismutase (SOD), glutathione peroxidase (GPx) and catalase (CAT) were examined. The concentration of GSH and the activity of studied enzymes did not show statistically signifi cant differences between control and gentamicin-exposed group. The pathological changes were not observed in the trunk kidney structure. Renal tubules as well as renal corpuscles had correct structure. The obtained results indicate that a single injection of gentamycin at a dose of 5 mg·kg–1 does not lead to disturbance of oxidant-antioxidant balance or histopathological changes in the trunk kidney of Prussian carp. Gentamicin administration did not change oxidoreductive balance and trunk kidney microstructure in Prussian carp (Carassius gibelio).