Diabetes | 2019
241-LB: Identification of Novel and Population-Specific Signals for Type 2 Diabetes in Large-Scale Study of Hispanic/Latino Individuals
Abstract
Hispanic/Latino populations are both disproportionately burdened by type 2 diabetes (T2D) and drastically less studied compared to non-Hispanic whites. We present results of the final data freeze of the DIAMANTE Hispanic/Latino Consortium, comprising the largest genome-wide meta-analysis and transcriptome-wide association study of T2D in a Hispanic/Latino population and including a total of 13,151 T2D cases and 21,511 controls. We identified a novel locus in an intronic region of BACE1 for T2D adjusted for body mass index, which has previously been linked to gestational diabetes susceptibility, but never before to T2D. We also identified two variants in known loci with evidence (p Disclosure L.E. Petty: None. J.E. Below: None.