1201-P: Monocyte Reprogramming in Nonhuman Primate Mother-Child Dyads Based on Maternal Health and Obesity Status

Abstract

The developmental origins of metabolic disease mechanisms are mostly unknown. Up to 40% of obese women are healthy, while roughly 15% of lean women are not. The implications for their children are difficult to disentangle from environmental factors. We assessed offspring from age-matched female African green monkeys (AMGs [n=44]) classified as metabolically healthy lean (MHL), healthy obese (MHO), unhealthy lean (MUL), and unhealthy obese (MUO) based on adjusted metabolic syndrome criteria (waist >40cm, fasting glucose (FG) >100 mg/dL, SBP >135/DBP >85mmHg and HDL-c Disclosure A. D. Ruggiero: None. M. Block: None. R. Vemuri: None. M. Davis: None. D. Destephanis: None. K. Kavanagh: None.