36-LB: The Effect of Dietary Carbohydrate Restriction on Health-Related Quality of Life and Cognition: A Randomized Trial

Abstract

Objective: We aimed to evaluate the effect of weight loss induced by a carbohydrate-reduced high-protein (CRHP) diet on physical and mental health and cognition. Methods: In this randomized parallel trial, 72 adults with type 2 diabetes and overweight or obesity (mean±SD, HbA1c: 7.4±0.7% and BMI: 33±5 kg/m2) were randomly assigned to CRHP diet (C30E%/P30E%/F40E%) or control diet (CD: C50E%/P17E%/F33E%) for 6 weeks. The two diets were intended to induce similar weight losses (~6%). Physical and mental component summary (PCS and MCS) scores were assessed from the short-form 36 questionnaire (SF-36), and global cognition, verbal memory, psychomotor speed and executive function from a neuropsychological test battery. Results: Both groups achieved a 5.8 kg (~6%) weight loss and improved PCS (median (IQR), CD: 2.7 (1.1;4.2)% and CRHP: 2.1 (0.7;3.7)%; both p Conclusion: Weight loss improves physical health independently of diet composition, and carbohydrate restriction may further benefit mental health, without adversely affecting overall cognition. Disclosure N. J. Jensen: None. S. Madsbad: Advisory Panel; Self; AstraZeneca; Boehringer Ingelheim; Eli Lilly; Merck Sharp & Dohme; Novo Nordisk; Sanofi, Research Support; Self; Novo Nordisk, Boehringer Ingelheim, Speaker’s Bureau; Self; AstraZeneca; Boehringer Ingelheim; Merck Sharp & Dohme; Novo Nordisk; Sanofi. F. Magkos: None. K. Miskowiak: Consultant; Self; Lundbeck. J. Rungby: None. S. B. Haugaard: None. T. Krarup: None. M. N. Thomsen: None. H. Z. Wodschow: None. M. J. Skytte: None. A. Samkani: None. A. Astrup: Consultant; Self; Groupe Ethique et Sante, France, Employee; Self; Novo Nordisk Foundation, Other Relationship; Self; Flaxslim ApS, Denmark, Gelesis, Personalized Weight Management Research Consortium ApS (Gluco-Diet. dk). J. Frystyk: n/a. B. Hartmann: None. J. J. Holst: Consultant; Self; Novo Nordisk, Other Relationship; Self; Antag Therapeutics, Bainan Biotech, MSD Corporation, Novo Nordisk, Other Relationship; Spouse/Partner; Antag Therapeutics, Bainan Biotech, Synklino ApS. T. M. Larsen: None. Funding Arla Foods; Danish Dairy Research Foundation