Archive | 2021
The Bihormonal Bionic Pancreas Improves Glycemic Control in Individuals With Hyperinsulinism and Postpancreatectomy Diabetes— A Pilot Study
Abstract
Objective: To determine if the bihormonal bionic\npancreas (BHBP) improves glycemic control and reduces hypoglycemia in\nindividuals with congenital hyperinsulinism (HI) and post-pancreatectomy\ndiabetes (PPD) compared with usual care (UC).\n\nMethods: Ten subjects with HI and PPD completed\nthis open-label, crossover pilot study. Co-primary outcomes were mean glucose concentration\nand time with continuous glucose monitoring (CGM) glucose concentration <3.3\nmmol/L.\n\nResults: Mean (SD) CGM glucose concentration was\n8.3 mmol/L (0.7) in the BHBP period vs. 9 mmol/L (1.8) in the UC period (p=0.13).\nMean (SD) time with CGM glucose concentration <3.3 mmol/L was 0% (0.002) in\nthe BHBP period vs. 1.3% (0.018) in the UC period (p=0.11). \n\nConclusion: \nRelative to UC, the BHBP resulted in comparable glycemic control in our\npopulation.