Safety and efficacy of recovery-promoting drugs for motor function after stroke: A systematic review of randomized controlled trials.

Abstract

OBJECTIVE\nTo investigate the efficacy and safety of drug interventions to promote motor recovery post-stroke.\n\n\nDATA SOURCES\nCENTRAL, CINAHL, Embase, MEDLINE, SCOPUS and Web of Science.\n\n\nSTUDY SELECTION\nPublished human randomized controlled trials in which the primary intervention was a drug administered to promote motor recovery post-stroke, vs placebo.\n\n\nDATA EXTRACTION\nStandardized pro forma used to extract safety and efficacy data; Cochrane Collaboration risk of bias assessment tool performed to assess risk of bias.\n\n\nDATA SYNTHESIS\nFifty randomized controlled trials from 4,779 citations were included. An overall trend of high risk of attrition (n\u2009=\u200927) and reporting bias (n\u2009=\u200936) was observed. Twenty-eight different drug interventions were investigated, 18 of which demonstrated statistically significant results favouring increased motor recovery compared with control intervention. Forty-four studies measured safety; no major safety concerns were reported.\n\n\nCONCLUSION\nCandidate drug interventions promoting motor recovery post-stroke were identified, specifically selective serotonin reuptake inhibitors and levodopa; however, the high risk of bias in many trials is concerning. Drugs to improve motor function remain an important area of enquiry. Future research must focus on establishing the right drug intervention to be administered at an optimal dose and time, combined with the most effective adjuvant physical therapy to drive stroke recovery.