Detection of Milimeter Wave Properties of Beta Amyloid using Dielectric Filled Truncated Cylindrical Waveguide

Abstract

Alzheimer’s disease (AD) is most common type of degenerative disorder, which is associated with the extracellular aggregation of beta-amyloid plaques [1] and intracellular neurofibrillary beta tangles [2] in the brain. Aggregation of amyloid and tangles from nm to hundred of μm range make them exciting for studying the dielectric properties [3]. These properties change as betaamyloid and tangles are exposed to the external stimulus. In this paper, transmission properties of beta amyloid have been experimentally analyzed using dielectric filled truncated cylindrical sensor at different microwave frequency up to 30 GHz. Fundamental frequency of the sensor is 5.6 GHz. To perturb the beta-amyloid, we have used ultra low frequency electric field as external stimuli. It has been reported that diseases could be cured by exposing the associated biomolecules into an electric field. Therefore this study can be helpful for the AD treatment by perturbing its dielectric properties.