Effect of the Perioperative Intravenous Lidocaine Infusion of 1.25 mg/kgBW/H on the Bowel Sound Recovery and Pain Intensity after Laparoscopic Cholecystectomy

Abstract

The purpose of this research is to assess the effect of perioperative intravenous lidocaine infusion of 1.25mg/kgBW/H on the bowel sounds recovery and pain intensity after laparoscopy cholecystectomy. The research used the experimental method, i.e. 42 patients who met the inclusive criteria and who would undergo laparoscopic cholecystectomy surgery under the general anesthesia, using the randomized double blind technique, and then were divided into two groups. The Treatment Group (KL, n = 21) received perioperative intravenous lidocaine infusion of 1.25 mg/kgB/H, while the control group (KN, n = 21) received the perioperative infusion of placebo of 0.9 NaCl. After the surgery, the assessments of the bowel sounds recovery time, the NRS scores at 2h, 6h, 12h, and 24h and the fentanyl requirement within 24 hours with PCA were conducted. The data were analyzed using the Chi square test, independent-t test, and Mann-Whitney test with p 0.05). The postoperative fentanyl requirement was lower in KL group (114.29 ± 31.196) mcg compared to the KN group (258.33 ± 27.764) mcg with p=0.000. The Perioperative intravenous lidocaine infusion of 1.25 mg/kgBB/h could speed up the bowel sounds recovery and reduce the pain intensity after laparoscopic cholecystectomy.