BIOLOGICAL EFFECTS OF C-PEPTIDE AND PROINSULIN: WE JIBE TOGETHER

Abstract

Discovery of Insulin marked a paradigm shift in the management of diabetes patients. Over the years as research in different types of insulin advanced the management of diabetes improved. However there were still many unanswered question pertaining to the use of insulin and its precursors. One such intriguing compound is C-peptide. Recently the role of C-peptide has opened many avenues in the treatment of diabetes. Large number of studies has demonstrated that lack of C-peptide may exacerbate diabetes. In a large group of diabetes the replacement with Cpeptide, lead to marked amelioration of diabetes complications. Research has shown marked improvement in endoneural blood flow with C-peptide replacement. C-peptide previously was considered as an inert molecule, however with the discovery of large number of receptors of C-peptide the action of the hormones has turned out to b enigmatic. Further research is needed to ensure some of the question particularly the therapeutic implication of C-peptide is prevention of diabetes related complications. Mrinal Ranjan Srivastava, Farzana Mahdi*, Abbas Ali Mahdi*, Sharique Ahmad** and Anu Chandra* Department Of Community Medicine, Department Of Biochemistry*, Department Of Pathology** Era s Lucknow Medical College & Hospital, Sarfarazganj Lucknow, U.P., India-226003 ERA’S JOURNAL OF MEDICAL RESEARCH BIOLOGICAL EFFECTS OF C-PEPTIDE AND PROINSULIN: WE JIBE TOGETHER VOL.6 NO.1 Review Article Page: 103 ERA’S JOURNAL OF MEDICAL RESEARCH, VOL.6 NO.1 Dr. Anu Chandra Department Of Biochemistry Era’s Lucknow Medical College & Hospital, Lucknow-226003 Email: [email protected] Contact no: +91-8172857543 Address for correspondence Received on : 31-07-2018 Accepted on : 21-06-2019