Rose Exctracts and In-Vitro Inhibition of SARS-CoV-2 Spike: The Ace-2 Interaction

Abstract

Abstract Objective The study was performed to evaluate the novel potential of red rose extract to inhibit SARS-CoV-2 spike protein-Ace2 receptor interaction in vitro. Methods ACE2 receptors were His-labelled, and the interaction was studied by chemiluminescence after the addition of anti-His HRP and HRP substrate. The inhibition of SARS-CoV-2 and ACE2 was assessed in a dose-dependent sequence. Results The 50% inhibitory concentration was observed at 0.75 percent v/v of the rose extract, and the 90% inhibition was seen at about 1.8 percent v/v. Steam inhalation or nebulization could be simple methods of delivering rose extracts to the lower respiratory tract and pulmonary tissues. Conclusion Rose extracts have a potential for inhibition of SARS-CoV-2 and ACE2 receptor in vitro, which could add beneficial effects in Covid-19 treatment. Further tests need to be performed to study their therapeutic benefits in vivo.