Eficácia das injeções de toxina botulínica no tratamento da hiperidrose primária: uma meta análise

Abstract

Objective: To evaluate the effectiveness of applying botulinum toxin in the treatment of primary hyperhidrosis in its different sites of involvement. Methods: A meta-analysis was performed using the PubMed, Cochrane, Scopus, Scientific Electronic Library Online (SciELO) and Open Thesis databases. The keywords used were primary hyperhidrosis , treatment and botulinum toxin . Two reviewers performed independent protocols using a standard form, based on a pre-defined systematic review protocol, PRISMA. Results: The search protocol found 1096 articles in the initial selection, of which 14 studies were included. Homogeneity analysis showed a Cochran Test Q of 80.1242 (p=0.001) and a Higgins I² test of 96.24%. Symmetry was assessed by the asymmetry test of the funnel graph with a t-value of 2.9111 (p=0.0131). The data on adverse events were asymmetric and heterogeneous, justifying the use of the fixed effects model. Final Considerations: The use of botulinum toxin is safe and effective for the treatment of Primary Hyperhidrosis (Evidence Level 1b). Injections of toxins act as a palliative measure, promoting the cessation or reduction of sweat with an extremely variable duration of effect from 4 weeks to 6 months, and with few adverse effects.