Comparative study on therapeutic effect of wheat germ oil and sesame oil with some lipid-lowering drugs in local male rabbits with hyperlipidemia, induced by triton x-100: Physiological and histological study

Abstract

Hyperlipidemia is a heterogeneous group of disorders characterized by excess fat in the bloodstream, and it is considered the primary mediator of a cascade of atherosclerosis. Also, hyperlipidemia is associated with cardiovascular diseases (CVD), including coronary heart disease and stroke, and is one of the leading causes of mortality in developed and developing countries. The present study aimed to identify the therapeutic effect of wheat germ oil and sesame oil on induced hyperlipidemia by triton X-100 and compare their effect with Atorvastatin and Rosuvastatin on some biochemical parameters in local male rabbit serum, which included estimation of lipid profile levels (cholesterol, triglycerides, low-density lipoprotein (LDL), very low-density lipoprotein (VLDL), High-density lipoprotein (HDL), HDL-C, LDL-C, VLDL-C) and lipid peroxidation marker-Malondialdehyde (MDA);in addition to the histological effects of wheat germ oil, sesame oil, Atorvastatin and Rosuvastatin on Aorta tissues.