Intravitreal antiVEGF injections combined with laser retinopexy in acute and chronic central serous chotioretinopathy

Abstract

Purpose. To evaluate the efficacy of combined treatment (anti-VEGF intravitreal injection followed by laser retinopexy) compered with conservative treatment in patients with central serous chorioretinopathy (CSR). Methods. A retrospective study included 191 patients with CSC. Patients were divided into 3 groups. 104 patients (1st group) were treated with intravitreal anti-VEGF injections followed by laser retinopexy. 50 patients (2nd group) received a conservative treatment. 37 patients (3rd group) were switched from conservative treatment to intravitreal anti-VEGF injections. Best corrected visual acuity (BCVA), central foveal thickness (CFT) and resolution of subretinal fluid on optical coherence tomography (OCT) were assessed. Results. Resolution of CRF in all patients in the 1st group was achieved by the 3rd month of treatment, from 3 to 6 months in the 2nd group and the 3rd groups. Mean BCVA improved more rapidly in the 1st group. A well-defined IS/OS line on final OCT was more frequently detected in the 1st group. Conclusion. Intravitreal antiVEGF injections followed by laser retinopexy in patients with CSR results in shorter treatment period and better functional results. Key words: аnti-vascular endothelial growth factor, central serous chorioretinopathy.