THE STATE OF THE DOPAMINERGIC SYSTEM OF THE RATS’ BRAIN IN THE MORPHINE-ALCOHOLIC POST-INTOXICATION SYNDROME

Abstract

Background. Opioid addiction, which has arisen against the background of previous alcoholism (or vice versa), is an urgent problem in clinical practice. The change in dopaminergic neuromediation after the withdrawal of the combined effect of ethanol and morphine is currently not clear what was the goal for our study. Purpose. Study of metabolites of the dopaminergic system in the cerebral cortex, striatum and midbrain of rats after different periods of withdrawal of 5-day morphine-alcohol intoxication. Material and methods. The experiments were carried out on 43 white outbred male rats. Using the HPLC method, the levels of metabolites of the dopaminergic system were determined after the withdrawal of the combined administration of morphine and ethanol. Results and conclusions. The severity of changes in metabolites of the dopaminergic system during morphinealcohol withdrawal is determined by the duration and region of the brain. One day after the withdrawal of both psychoactive substances in the striatum and cerebral cortex, a decrease in the concentration of dopamine was observed. In the long-term periods of abolition of intoxication with morphine and ethanol (3, 7 days), the processes of acceleration of dopamine turnover in the midbrain and a decrease in the concentration of the neurotransmitter in the striatum were revealed.