DOPAMINERGIC SYSTEM OF THE HYPOTHALAMUS AND STRIATUM OF THE RAT BRAIN WITH THE COMBINED EFFECTS OF ACUTE ALCOHOL INTOXICATION AND PHYSICAL INACTIVITY

Abstract

Background. The growth of industrialization is accompanied by a decrease in human motor activity, and chronic stress increases the risk of alcoholism. The combination of these factors has a negative effect on the physiological and biochemical processes in the body. Purpose of work. To determine the state of the components of the dopaminergic system in the hypothalamus and striatum of rats during acute alcoholization against the background of hypodynamia. Material and methods. The experiment was carried out on male rats weighing 180-200 g, which, after hypodynamia for a period of 7, 14 and 28 days, were once injected with 25% alcohol at a dose of 3.5 g / kg. The content of the components of the dopaminergic system was determined by high performance liquid chromatography. Results. The striatum is characterized by a decrease in the activity of the dopaminergic system on the 7th day of hypodynamia, followed by its activation with an increase in the period of immobilization to 28 days. In the hypothalamus in the early stages of hypodynamia with subsequent OAI, the changes are poorly expressed, however, on the 28th day, dopamine turnover is activated. Conclusions. The combined effect of acute alcohol intoxication and hypodynamia leads to more pronounced changes in the dopaminergic system in the striatum than in the hypothalamus. Acute alcohol intoxication has a stimulating effect on the dopaminergic system of the hypothalamus and striatum only for long periods of hypodynamia (28 days).