Archive | 2021
Анализ показателей системы фибринолиза и состояния сосудистой стенки в крови новорожденных, родившихся у материей с преэклампсией:
Abstract
Summary. Background. Neonates born to mothers with pathology during pregnancy are at high risk of thrombotic and hemor- rhagic complications that are increased if neonates have perinatal pathology. Objectives: to assess blood parameters characterizing fibrinolysis and vascular wall of neonates born to mothers with preeclampsia (РЕ), to predict the risk of hemorrhagic complica- tions in these children. Patients/Methods. 60 neonates born to mothers with РЕ were examined. The control group consisted of 30 neonates born to mothers without РЕ. We studied levels of tissue plasminogen activator (t-PA), inhibitor of tissue plasminogen activator (PAI-1) and thrombomodulin (TM) in venous blood taken from neonates on the 3–5th days of life. Results. In neonates born to mothers with PE we revealed on the 3–5th days of life increased blood levels of t-PA, PAI-1 and TM that characterized endothelial damage and increased blood fibrinolytic activity. Conclusions. The data obtained indicate the risk of hemorrhagic complications development in these children. \n \n \n \nReferences: \n \n \n \n \nKuznik B.I. Cellular and molecular mechanisms of regulation of the hemostasis system in norm and pathology. Chita: N’yudiamed, 832 pр. (In Russ.). \u2028 \nAlieva L.B. Present views on the neonatal hemostatic system. Ros- sijskij vestnik perinatologii i pediatrii. 2011;5:19–24. (In Russ.). \u2028 \nIvanov A.V.Hemostasis dieorders during pregnancy: clinical and diagnostic aspects. Laboratornaya medicina. 2014;11(4):60– 3. (In Russ.). \u2028 \n\u2028Sukhikh G.T., Serov V.N., Adamyan L.V. et al. Hypertensive dis- orders during pregnancy, childbirth and the postpartum period. Eclampsia. Problemy reprodukcii. 2018;24(S6):80– 114. (In Russ.). \u2028 \nPisaneschi S., Boldrini A., Genazzani A.R. et al. Feto-placental vascular dysfunction as a prenatal determinant of adult cardio- vascular disease. Intern Emerg Med. 2013;8(1):41–5. DOI: 10.1007/ s11739–013–0925-y. \u2028 \nPylaeva N. Yu., Shifman E.M., Kulikov A.V. et al. Preeclampsia. Eclampsia. Anesthesia and intensive care in childbirth and the Review. Vestnik intensivnoj terapii imeni A.I. Saltanova. 2020;(1):41–52. (In Russ.). DOI 10.21320/1818–474X-2020–1–41–52. \u2028 \nPanova I.A., Rokotyanskaya E.A., Kuzmenko G.N. et al. The mark- ers of inflammation reaction and dysfunction of endothelium in pregnant women with hypertension disorders of various gene- sis. Klinicheskaya laboratornaya diagnostika. 2016;61(10):692–6. (In Russ.). DOI: 10.18821/08692084–2016–10–692–696. \u2028 \n\u2028Popova I.G., Chasha T.V., Kuzmenko G.N. et al. Perinatal CNS lesions in neonate born to mothers with gestosis. Rossijskij vestnik perinatologii i pediatrii. 2010;4(55):18–22. (In Russ.). \nShilova N.A., Chasha T.V., Khoroshilova A.G. et al. Method for predicting bronchopulmonary dysplasia in children with con- genital pneumonia. Patent RF No 2439569 ot 10.01.2012. Byul. No 1. 9 рp. (In Russ.). Available at: https://patents.s3.yandex.net/ RU2439569C1_20120110.pdf. \nSamsonovaT.V.,BobrovaE.A.,KuzmenkoG.N.,PopovaI.G.Method for predicting motor development disorders in children of the first year of life with perinatal hypoxic brain lesions. Patent RF No 2319154 ot 10.03.2008. Byul. No 7. 6 pр. (In Russ.). Available at: http://www.freepatent.ru/images/patents/148/2319154/pat- ent-2319154.pdf. \nKuzmenko G.N., Nazarov S.B., Popova I.G. et al. Method for predict- ing intraventricular hemorrhages in premature newborns. Patent RF No 2303782 ot 27.07.2007. Byul. No 21. 7 pр. (In Russ.). Available at: https://patents.s3.yandex.net/RU2303782C2_20070727.pdf. \n \n \nKuzmenko G.N., Nazarov S.B., Popova I.G. et al. Innovative tech- nology in the evaluation of the haemostatic potential of blood of preterm neonates. Rossijskij pediatricheskij zhurnal. 2015;18(2):4– 10. (In Russ.). \n \n \nTretyakova O.S. Hemostasis features in neonatal period. Dityachij likar. 2011;1(8):26–34. (In Russ.). \nKoltsova E.M., Balashova E.N., Panteleev M.A., Balandina A.N. Lab- oratory aspects of hemostasis in neonates. Voprosy gematologii/ onkologii i immunopatologii v pediatrii. 2018;17(4):100–13. (In Russ.). DOI: 10.24287/1726–1708–2018–17–4–100–113. \n \n \nSzpecht D., Szymankiewicz M., Nowak I., Gadzinowski J. Intra- ventricular hemorrhage in neonates born before 32 weeks of gestation-retrospective analysis of risk factors. Childs Nerv Syst. 2016;32:1399–404. DOI: 10.1007/s00381–016–3127-х. \nBhat R., Monagle P. The preterm infant with thrombosis. Arch Dis Child Fetal Neonatal Ed. 2012;97:423–8. DOI: 10.1136/archdi- schild-2011–301142. \nRuzmetova G.B., Gulyamova M.A., Tursunkhodzhaeva N.A., Khozhi- metov Kh.A. Hemostasis disturbances in newborns with intraven- tricular hemorrhages. Molodoj uchenyj. 2016;(23):159–62. (In Russ.). \nKizilova N.S. Clinical and laboratory diagnostics of hemostasis, principles and schemes. Novosibirsk, 2007. 216 pp. (In Russ.). \nNako Y., Ohki Y., Hariqaya A. et al. Plasma thrombomodulin level in very low birthweight infants at birth. Acta Pediatrica. 1997;86(10):1105–9. \nMamaev A.N. Practical hemostasiology: a guide for physicians. Moscow: Prakticheskaya medicina, 2014. 240 pp. (In Russ.).