Оценка ферментных систем десны на фоне применения милдроната при экспериментальном пародонтите

Abstract

A histochemical analysis of the state of enzyme systems of the gum in experimental periodontitis with the use of mildro-natewere presented.10-20 days after the formation of the periodontitis model in rats, the activity of alkaline and acid phosphatases, lipoamide dehydrogenase and nonspecific AS-esterase increases in the background of systemic application of mildronate in the gingival tissues, and the activity of lactate dehydrogenase and succinate dehydrogenase decreases.In later terms (40-60 days), the use of the drug almost does not change the activity of acidic and alkaline phosphatases. In contrast to the control, in the late period of periodontitis development, mildronate reduces the activity of lactate dehydrogenase, lipoamide dehydrogenase and nonspecific AS-esterase, the most significant being a decrease in the activity of the isoenzyme fractions of lactate dehydrogenase-3 and AS-esterase-1.