Relationship between Cognitive Impairment and Serum Amyloid β-Protein , Adiponectin as well as CRP Levels in Type II Diabetes

Abstract

Objective: The purpose of this study was to explore the plausible mechanism of type 2 diabetes patients’ cognitive impairment by analyzing the levels of serum amyloid β-protein (Aβl-42), adiponectin and CRP. Methods: We chose 84 patients diagnosed with type 2 diabetes and 60 healthy people as subjects. Clinical data were collected by Self-made questionnaires. The Repeatable Battery for the Assessment of Neuropsychological Status (RBANS) scales was used to access the cognitive functions. The serum Aβl-42 and adiponectin levels were individually determined with ELISA. C-reactive protein was detected by Siemens BNP II specific protein analyzer. Results: Immediate memory, visual span, speech function, attention and delay memory scores of RBANS scale and standard scores in the case group were significantly lower than the control group. Aβl-42 levels in the case group were significantly higher than the control group. Age of patients was significantly negative related to RBANS scale subtest scores and standard scores in the case group. Years of schooling was significantly positive correlated to immediate memory, visual span, attention, delay memory scores and standard scores, while negative correlated with J Bioinform Syst Biol 2019; 2 (2): 043-052 DOI: 10.26502/fjbsb007 Journal of Bioinformatics and Systems Biology 44 speech function; after adjusting ages and years of schooling, Aβl-42 levels of patients in the case group were significantly negative, correlated with immediate memory, attention, delay memory scores and standard scores (p<0.05). Adiponectin levels of patients in the case group were positive correlated with RBANS scale subtest scores and standard scores (p<0.05). Conclusions: Type 2 diabetes patients suffer from cognitive impairment and the mechanism may be associated with increased serum Aβl-42, and decreased adiponectin and inflammation reaction. Detection of serum Aβl-42 and adiponectin could be used as an indicator for the degree of cognitive impairment in Type 2 diabetes patients.