Alteration of NADH Succinate Dehydrogenase Activity and Redox Status By Different Solvent Fractions ofAntiaris Africana in the Brain of Rats Exposed ToRotenone

Abstract

Excessive reactive oxygen species (ROS) production can outweigh cellular antioxidant defenses leading to oxidative stress (OS). This process has been consistently linked to age-related neurodegenerative diseases Recently, research has focused on the role of OS in neurodegenerative disorders Oliveira et al. [1]. Some of the features of brain include high dependence on oxygen for all its metabolic activities, high concentration of oxidizable fatty acids, reduce ability of cell regeneration and low levels of antioxidant enzymes Kumar et al. [2]. One of the key organelles involved in OS is the mitochondria, it is central to most of the biological function linked to oxidative metabolism, such as energy conversion for ATP synthesis, ion homeostasis, fatty acid biosynthesis, iron sulfur cluster biogenesis, calcium storage, and importantly the cell death pathways Spinazzi et al. [3]. Abstract