Antibiotic Susceptibility Profile of Lactic Acid Bacteria with Probiotic Potential Isolated from Humans

Abstract

Emergence of multidrug resistance bacteria is a significant health threat globally. Administration of antibiotics against pathogens causes dysbiosis of gut and development of multidrug resistant strains within the gut and thereby spread of resistance through horizontal and vertical transfer of resistant gene [1]. An alternative to reduce the usage of antibiotics is probiotics, the beneficial microorganisms inhabiting gut. Lactic acid bacteria (LAB) is the most exploited probiotic group which is administrated orally as food supplements and as pharmaceuticals. Probiotics are generally regarded as safe due to lack of pathogenicity. The additional health benefit of LABs like tolerance to lactose, reduction in severity of antibiotic associated and infectious diarrhea, antibacterial effects, anticancer and antimutagenic activity antiinflammatory and protective effects in IBD, cholesterol assimilation etc. increases its use in food and pharmaceutical products [2].