The Effects of Ethanol Extract and Ethyl Acetate Fractionation of Sechium Edule Jacq. Swartz on Triglyceride Levels in Male Rats with Type 2 Diabetes Mellitus

Abstract

Background: The prevalence of diabetes mellitus (DM) from year to year is increasing. Hyper\xadglycemia that occurs in DM is caused by oxidative stress that damages pancreatic β cells. This situation can be controlled with synthetic hypoglycemic drugs, but it requires high medical costs. Therefore, alternative therapies that are easily available, relatively inexpensive, have potential anti-hypoglycemia and anti-cholesterolemia which is found in conjoined flasks ( Sechium edule (Jacq.) Swartz ) which contains flavonoids are needed. The purpose of this study was to analyze the effectiveness of ethanol extract and fractionation of ethyl acetate extracts of Sami (pumpkin) ( Sechium edule (Jacq.) Swartz ) as anti-hipoglycemia and anti-hypertriglycerides in white male wistar rats ( Rattus novergius sp. ) induced by STZ-NA-HFDD. Subjects and Method: A randomized controlled trial was conducted to assess the effectiveness of ethanol extract and fractionation of pumpkin fruit ethyl acetate extract. The sample included white male wistar rats ( Rattus novergius sp .) Hyperglycemia induced by STZ-NA-HFD. The dependent variable was triglyceride levels. The independent variables were administration of ethanol extract and fractionation of pumpkin fruit ethyl acetate extract. Results: Ethyl acetate fraction 45 mg/kgBW better reduce triglyceride levels but statistically does not have significant differences between groups. Conclusion: The group that received Metformin and the group that was given ethanol extract 45 mg/kgBW had lower triglyceride levels compared to the other therapy and control groups. Keywords: Hipertrigliseridemia, diabetes mellitus, STZ-NA-HFD Correspondence:\xa0 Jekson Martiar Siahaan. Department of Physiology, Faculty of Medicine, Universitas Methodist Indonesia. Jl. Setia Budi Pasar II Tj. Sari, Medan 20132, North Sumatera. Email: Jekson.siahaansked\xad@\xadgmail.com Indonesian Journal of Medicine (2019), 4(4): 371-375 https://doi.org/10.26911/theijmed.2019.04.04.10