Effect of Curcuma Longa Rhizome Extract on Fasting Blood Sugar Levels and HbA1C in Type 2 Diabetes Mellitus: A Meta-Analysis

Abstract

Background: Diabetes mellitus (DM) is a metabolic disease that is developing into a serious global problem. Diabetes mellitus is characterized by an increase in blood levels that are more than the normal reference. In type 2 DM generally occurs due to reduced insulin secretion and sensitivity over time. Control of blood sugar levels can improve the patient s quality of life. This study aimed to analyze the effect of curcuma longa rhizome extract on fast\xading blood sugar levels and HbA1C in patients with type 2 diabetes. Subjects and Method: This was a meta-analysis of a number of randomized con\xadtrolled trials. The articles were obtained from PubMed, Google Scholar, Springerlink, BMJ, and Sci\xadencedirect data\xadbases, published from 2010-2020. The article search was carried out by con\xadsidering the eligibility criteria defined using the PICO model. P: Type 2 diabetes patients, I: Cur\xadcuma longa rhizome extract, C: Placebo, and O: Fasting blood sugar levels and HbA1C. The keywords to find articles are as follows: Curcuma longa , OR Curcu\xadmin OR Tume\xadric OR Curcuma AND Fast\xading blood glu\xadcose AND HbA1C OR Glice\xadmic OR Dia\xadbetes Mellitus AND Rando\xadmized Controll Trials . Articles were collected using PRISMA flow diagrams. Articles were analyzed using the Review Manager 5.3 application. Results: A total of 14 articles were reviewed in this study. Meta-analysis of 12 articles showed that the curcuma longa rhizome extract reduced fasting blood sugar levels (Stan\xaddar\xaddized Mean Diffe\xadrence= -0.48; 95% CI= -0.61 to -0.34; p <0.001). The meta-analysis of 11 articles showed that admi\xadnis\xadtration of curcuma longa rhizome extract decreased HbA1C levels (Standardized Mean Difference= -0.40; 95% CI= -0.59 to -0.20; p <0.001). This meta-ana\xadly\xadsis combines primary studies from Iran, Japan, Thailand, China, Mexico, Brazil, and Australia Conclusion: Curcuma longa rhizome extract reduces fasting blood sugar and HbA1C levels in patients with type 2 diabetes. Keyword s : Curcuma longa, Fasting blood sugar levels, HbA1C, diabetes mellitus type 2, randomized controlled trial Correspondence:\xa0 Riska Fajar Fatony. Masters Program in Public Health, Universitas Sebelas Maret. Jl. Ir. Sutami 36A, Surakarta 57126, Central Java. Email: [email protected]. Indonesian Journal of Medicine (2021), 06(02): 119-134 https://doi.org/10.26911/theijmed.2021.06.02.01