Actualización en el tratamiento de las reacciones adversas cutáneas graves a los medicamentos

Abstract

In contrast to the frequently skin eruptions related to drug reactions, the severe presentations such as drug hypersensitivity syndrome with eosinophilia and Stevens-Johnson syndrome/toxic epidermal necrolysis spectrum, can have life threatening complications. Investigations evaluating the treatment of these entities are conditioned by the critical status and the low incidence of cases, making high quality evidence limited and the most effective therapy cannot be established. This article reviews commonly applied systemic treatments in adult patients, the physiopathological substrate, therapeutic schemes and most frequent unwanted effects. Also describes new alternatives that offer potential applications.