High Protein Diet Improves Biochemical and Metabolic Hormonal Profile in Alloxan-Induced Diabetic Rats

Abstract

Received: Revised: Accepted: Published online: August 28, 2018 January 16, 2019 January 18, 2019 January 28, 2019 Diabetes mellitus is a metabolic disorder characterized by high blood glucose level due to defective insulin secretion or action and is considered one of the major concerns to human health all over the world. Current study was planned to assess the effects of protein rich diet on body weight, glycemic control, insulin levels in hyperglycemic rats. For this purpose, high protein diet (45% or 55% fish protein rich in omega 3 fatty acids) was administered to alloxan-induced diabetic rats for a period of 28 days. Blood samples were collected for monitoring glucose level, serum insulin level and thyroid hormone levels. Alloxan administration resulted in reduced body weight, increased blood glucose, leptin while decreased insulin, amylin, glucokinase, thyroid stimulating hormone (TSH), triiodothyronin (T3) and thyroxin (T4) levels. High protein diet significantly restored body weight and showed significant anti-diabetic effect by reducing serum glucose and increasing serum insulin level in comparison to positive control (diabetic) group. Use of high protein diet also normalized serum amylin, leptin, GCK, T3, T4 and TSH. In sum, these results indicated the anti-hyperglycemic potential of high protein diet in alloxan-induced diabetic rat model. ©2019 PVJ. All rights reserved