Immunohistochemical and Histological Features of a Spontaneous Leydig Cell Tumour in a Rat

Abstract

Received: Revised: Accepted: Published online: December 30, 2018 February 20, 2019 April 16, 2019 May 25, 2019 Neoplastic testicular lesions are diagnosed increasingly frequently in dogs and humans. In rats, spontaneous testicular tumours, particularly Leydig cell tumours, are very rare. The aim of the study was to carry out a histological and immunohistochemical analysis of a Leydig cell tumour in a rat as well as to present the similarities and differences in the expression of the proteins used to diagnose this type of tumour in dogs and men. Following the histopathological and immunohistochemical analysis (including antibodies against vimentin, calretinin, inhibin-α, β catenin and E-cadherin), significant similarities were found in the level of expression of the studied cell markers of the rat, dog and male leydigoma This indicates their usefulness as diagnostic markers of testicle tumours both in humans and animals. ©2019 PVJ. All rights reserved