A Review Article on Floating Drug Delivery System Used in Treatment of the Depression

Abstract

The purpose of written on review on the Floating drug delivery system use in treatment of depression is the main object on floating drug delivery system mechanism, needs and application and the main focus on used in treatment in depression mental state, floating drug delivery system is extreme valuable process and capability to prolong and control the gastric emptying time which domicile in the stomach for long time and floating system is more significance in enhancement of bioavailability and minimize the drug wastages, depression is most serious mental state today many people is know that depression not disease but it is serious mental disease which is cause anxiety etc. And floating drug delivery system is very useful on those drug which have lower bioavailability and in this disease. And in this mental state patients not want to take medicine two to three times because they not feel good and normal and floating system is most useful for patients compliance so floating drug delivery system is very applicable in anti-depressant drug for example Venlafaxine hydrochloride. Key wordGastro retentive system, Floating drug delivery system, Depression INTRODUCTIONOral drug delivery system is aid to arrive to resistance to change of position therapeutic plasma drug concentration in to the preparation. These drug dosage forms disclose good patient compliance and assumption drug release profiles. Moreover these were not constructed to counter the difficulties attached with physiological position of the human body that are gastric emptying which more important effectual the bioavailability and in turn the curative capacity to produce a desired effectual of the drug dosage forms. Thus gastro retentive dosage forms such as hydrodynamic balanced systems, modify density system, GIT release the drug in absorption zone and extended the gastric residence duration by antagonistic gastric emptying method. The groups can controller release of the drug in absorption zone before eviction of the dosage form from the human body thence make proper the bioavailability of the drug. Gastric emptying of dosage forms is an utmost various method and capability to extended and control emptying time is vital plus for dosage forms, which domicile in the stomach for a large time than conventional dosage forms, while the dosage form is lower absorption/non absorbing phase. These kinds of problems defeat by the floating drug delivery system. It is the gastro retentive drug delivery system. GASTRO-RETENTIVE SYSTEMGastro retentive system can stay in the gastric site for many hours and thence importantly extended the gastric retention made better bioavailability minimize drug wastage and make better, solubility of drugs that are less soluble in high pH environment. Gastric retention generate newer curative possibilities and substantial profits from patients. Gastro-retentive system are those dosage form which is able for retain itself in the stomach of gastric content to maximizing the produce absorption drug from medium of acidic in control manner. Gastro retentive system are favourable drug which is improving their. • Bioavailability • Therapeutic effective • Possible reduction • Reduces drug wastage • Rise solubility for drug that are less soluble in high pH FLOATING DRUG DELIVERY SYSTEMInternational Journal of Scientific and Research Publications, Volume 9, Issue 4, April 2019 359 ISSN 2250-3153 http://dx.doi.org/10.29322/IJSRP.9.04.2019.p8849 www.ijsrp.org Floating drug delivery system are less density which buoyancy is capable amount for float over the gastric content. It stay buoyant in stomach without affective gastric empty retention time. Conclusion maximize the gastric retention time for better control of fluctuation in plasma drug concentration. Devis is primarily introduce the floating system that floating drug delivery system to use the difficulty of swelling of dosage form and presented the modern gastro retentive drug delivery system to the pharmaceutical or pharmacy industry. Today the more of effectual control drug release dosage form. FLOATING DRUG DELIVERY SYSTEM The main purpose of floating drug delivery system is arrive assuming and maximize in bioavailability. Today pharmaceutical scientist are mostly participate in development of floating drug delivery system. The dosage form has vantage of once dose for cure and should be deliver the active drug material directly at specific site. Floating system is beneficial as drug with narrow absorption window, which is importance for local action to other dosage form of tablets which are absorbed in the stomach. Floating drug delivery system will maximize the bioavailability of the drug from by floating dosage form in the stomach for large duration and produce for extended time and these several kinds of system are significant for narrow absorption. Useful the special category of the dosage form. Gastric emptying is most fast in fasting stage, bulky in the presence of food to slow emptying and give important liquid for efficient buoyancy. NEEDS OF FLOATING DRUG DELIVERY SYSTEM• The Transitional gastric emptying time is reason of drug absorption. • Drugs which are absorbed from the site of gastro intestinal tract. • Local delivery system or sustained drug delivery system from the stomach. • Drugs which are low soluble or degrade in alkaline. They are encounter at the gastro intestinal lower part. • Mostly applied in cure in peptic ulcer. IDEAL CHARACTERSTICS OF FLOATING DRUG DELIVERY SYSTEM• The floating drug delivery system is should be maximize the bioavailability. • It should be provide beneficial systematic effectual. • Applied of those substance which provide maximum bioavailability. • Drugs, which are primarily absorbed in the stomach and upper site of gastro intestine. • The absorption of drug in gastro intestine tract with narrow window absorption. • The drug acts local in the stomach. • The drug which are unstable in the colon. • Should be enhancement effectual for in treatment and should be low adverse effect. • It should be nice stability. IMPORTANCE OF FLOATING DRUG DELIVERY SYSTEM• Drug dosing is low • The adverse effect of drug is low • The cure of gastric disorder is useful. • The dosage form of drug is applicable for firstly absorbed in gastro retentive intestinal tract. MECHANISM OF ACTIONIn this system after releasement of the dosage form, the residuary system is nothing to contained from the gastro intestinal tract, conclusion maximize the gastro retentive time and better determine the fluctuation in the plasma drug concentration. Static, Moreover a lowest gastric content useful to permit the appropriateness accomplishment of buoyancy retention base, a lower flat of the floating force (F) is permit is needful the jog the drug dependable buoyant on the surface of the repast. Lower gastric content is useful to permit the accomplishment rightness for buoyancy F is the function duration that needful primary International Journal of Scientific and Research Publications, Volume 9, Issue 4, April 2019 360 ISSN 2250-3153 http://dx.doi.org/10.29322/IJSRP.9.04.2019.p8849 www.ijsrp.org recessed the object first is the float is nice F is on maximize positive side. The setup is needful in bar the hindrance, the buoyancy ability fluctuation. F= f buoyancy-F gravity= (Df-Ds) gv Where F= total vertical Df= fluid density Ds= object density v= volume and g= acceleration due to gravity. MECHANISM ACTION OF THE FLOATING DRUG DELIVERY SYSTEM ADVANTAGES OF THE FLOATING DRUG DELIVERY SYSTEMThe legion of the floating drug delivery system are following as. • Extended release of the administered drug from the several kinds of the dosage form like tablets, capsules, microspheres of the system. • The Floating system is enhance the bioavailability. • This system is more desirable the proper of being selective in receptor activation. • Large effectual concentration. • For the local infirmity marked therapy of the method in the upper site of the gastro intestinal tract. FACTOR AFFECTING THE FLOATING DRUG DELIVERY SYSTEM• DENSITYDensity of the gastric retention time dosage form function from buoyancy which is to be contingent upon the density because of density of dosage form is effectual the gastric emptying rate, While buoyancy of the dosage form is effectual the gastric emptying rate, when buoyancy is lower than gastric emptying rate than system is float. • SIZE AND SHAPEThe size and shape of dosage form is also effectual the gastro retention, the ring contour of devices have superior to another gastric residence time as comparability with another shapes. • NATURE OF MEALEating of digested with difficulty polymers and fatty acid and salt can modify the form of the stomach hence minimizing the gastric emptying rate and extending the release of the drug. • GENDERLower gastric emptying rate of the female candidate than male candidates. • MENTAL STATEStress will be maximize in the gastric emptying rates whereas depression low it down. • AGE AND POSTUREElder candidate particular those over 70, have an important larger gastro retentive time. Slower the gastric emptying time of the duration ascertained in elder. Gastro-retentive time can alter between indolence and consecutive posture province of the patients. TYPE OF THE FLOATING DRUG DELIVERY SYSTEMThere are two types of the floating drug delivery systemA)-EFFERVESCENT TYPE OF FLOATING DRUG DELIVERY SYSTEMB)-NON EFFERVESCENT TYPE OF FLOATING DRUG DELIVERY SYSTEMEFFERVESCENT TYPEEffervescent type of the floating drug delivery system is also known as the gas generating system which is formulated by the aid of the swelling type polymer such as methyl cellulose, chitosan and several type of effervescent compound like sodium bicarbonate, tartaric acid and citric acid. The relative magnitudes of two quantities of citric acid and sodium bi carbonate is optimal stoichiometric for gas generating in the floating is slightly convexity of the drug delivery syste